• Anti-cancerous and anti-tumor research papers

    • Tumor cell growth inhibition by several Annonaceous acetogenins in an in vitro disk diffusion assayThis study shows that annonaceous acetogenins present in soursop stops cell growth for cancerous cells and it is also equally effective on drug resistant cancer cells. View this paper
    • Selective growth inhibition of human breast cancer cells by graviola fruit extract in vitro and in vivo involving downregulation of EGFR expressionThis study shows the effect of soursop fruit extract on human breast cancer cells and it shows that the growth of the cells is inhibited. View this paper


    • The Annonaceous acetogenin bullatacin is cytotoxic against multidrug-resistant human mammary adenocarcinoma cellsThis study shows that bullatacin, an acetogenin of soursop, reduces cellular energy and is toxic to multidrug-resistant cancer cells. View this paper


    • Graviola: a novel promising natural-derived drug that inhibits tumorigenicity and metastasis of pancreatic cancer cells in vitro and in vivo through altering cell metabolismPancreatic tumors become resistant to conventional chemotherapies. This study shows that graviola or soursop extract killed pancreatic cancer cells by blocking their access to the energy source ATP. View this paper


    • Annonacin induces cell cycle-dependent growth arrest and apoptosis in estrogen receptor- _-related pathways in MCF-7 cellsBreast cancer cells commonly become resistant to Tamoxifen. This study shows that annonacin(which in present in soursop) stopped cancer cells’ growth and reduced tumor size at 7-22 days. View this paper


    • Chemopreventive Potential of Annona Muricata L Leaves on Chemically-Induced Skin Papillomagenesis in MiceThis study shows that the extract of soursop leaves was able to suppress tumor before it started growing as well as growth of the tumor even at lower dosage. View this paper


    • Selective Action of Acetogenin Mitochondrial Complex I InhibitorsThis is a study on the acetogenins from various plants. Acetogenin from soursop proved to be toxic to selective bad cells and a panel of tumor cell lines including multidrug- resistant cells. View this paper


    • Quantitative Assessment of the Relative Antineoplastic Potential of the n-butanolic Leaf Extract of Annona Muricata Linn. in Normal and Immortalized Human Cell LinesQuantitative Assessment of the Relative Antineoplastic Potential of the n-butanolic Leaf Extract of Annona Muricata Linn. in Normal and Immortalized Human Cell Lines View this paper


  • Anti-depression properties

    • Isoquinoline derivatives isolated from the fruit of Annona muricata as 5-HTergic 5-HT1A receptor agonists in rats: unexploited antidepressive (lead) productsThis study shows the effect of isoquinoline, a compound present in the fruit soursop on rats and it shows an antidrepressive effect.View this paper


  • For herpes simplex virus

    • Effect of the extract of Annona muricata and Petunia nyctaginiflora on Herpes simplex virus This study shows the effect o extract of Annona muricata on Herpes Simplex virus. View this paper


  • Anti-diabetic properties

    • Anti Hyperglycemic Activities of Annona Muricata (Linn)This study shows that leaf extracts of soursop have anti-diabetic properties as it helps in reducing blood glucose level. View this paper


  • Hypotensive properties

    • Possible mechanisms of action of the hypotensive effect of Annona muricata (soursop) in normotensive Sprague–Dawley ratsThis study shows that leaves of the soursop caused significant reduction in blood pressure with only a slight affect on heart rates.View this paper


  • Anti-inflammatory properties

    • Antinociceptive and Anti-inflammatory activities of the ethanol extract of Annona Muricata L. leaves in Animal ModelsThis study shows that sourop leaves have tremendous pain-relieving and anti-inflammatory or anti-swelling properties. View this paper


*Analyses made at the Laboratorio FIM de Nutricion, Havana, Cuba.